Additional Resources

Human Health Science

Buekers J, De Brouwere K, Lefebvre W, Willems H, Vandenbroele M, Van Sprang P, Eliat-Eliat M, Hicks K, Schlekat CE, Oller AR. 2015. Assessment of human exposure to environmental sources of nickel in Europe: Inhalation exposure. Science of the Total Environment. 521-522: 359-371.

Efremenko A, Campbell Jr JL, Dodd DE, Oller AR, Clewell HK , 2017. Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel sulfate. Environ Mol Mutagen DOI 10.1002/em.22139.

Efremenko A, Campbell Jr JL, Dodd DE, Oller AR, Clewell HK, 2014.Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel subsulfide. Toxicol Appl Pharmacol. 279(3): 441-454.

Gray DL, Wallace LA, Brinkman MC, Buehler SS, La Londe C, 2014. Respiratory and Cardiovascular Effects of Metals in Ambient Particulate Matter: A Critical Review. Book_329441_RECT_ Volume 234, Chapter 3, Reviews of Environmental Contamination and Toxicology, DOI 10.1007/978-3-319-10638-0_3.

Haber LT, Bates HK, Allen BC, Vincent MJ, Oller AR, 2017. Derivation of an oral toxicity reference value for nickel. Regul Toxicol Pharmacol. 2017 Jun 15;87 Suppl 1:S1-S18. doi: 10.1016/j.yrtph.2017.03.011. Epub 2017 Mar 12.

Henderson RG, Verougstraete V, Anderson K, Arbildua JJ, Thomas O Brock, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon G, Odnevall Wallinder I, Rodriquez PH, Van Assche F, Wilrich P, Oller AR, 2014. Inter-laboratory Validation of Bioaccessibility Testing for Metals. Regul Toxicol and Pharmacol. 70(1): 170-181.

Nickel Institute, 2016. Workshop on Nickel Dermatitis. Chicago, Illinois, June 2016. Meeting report. pp 2. 

Oller AR, 2017. Letter to Editor of Basic & Clinical Pharmacology & Toxicology journal, regarding the mini review titled Is nickel chloride really a non genotoxic carcinogen? By Stannard et al. (DOI: 10.1111/bcpt.12689). Basic & Clinical Pharmacology & Toxicology, DOI: 10.1111/bcpt.12760.

Oller AR, Delbeke K, Verougstraete AR, 2015. Use of an effective concentration approach to classify alloys. presented at the Institut National de l’Environnement Industriel et des Risques. 2015 Occupational Health Research Conference on the topic of "Chemical risk: innovative methods and techniques" held in Nancy (France) April 08-10, 2015.

Oller AR, Oberdörster G, 2016. Incorporation of dosimetry in the derivation of reference concentrations for ambient or workplace air: a conceptual approach. J. Aerosol Science. 99: 40-45.

Oller AR, Oberdörster G, Seilkop S, 2014. Derivation of PM10 size-selected human equivalent concentrations of inhaled nickel based on cancer and non-cancer effects in the respiratory tract. Inhal Toxicol. 26(9): 559-578.

SLI (Springborn Laboratories Inc.), 2000a. A One-generation Reproduction Rangefinding Study in Rats with Nickel Sulfate Hexahydrate. Springborn Laboratories Inc., Spencerville. SLI Study No. 3472.3.

This range-finding study was conducted to evaluate the potential effects of nickel sulfate hexahydrate when administered orally to rats over the course of one generation.

SLI (Springborn Laboratories Inc.), 2000b. An Oral (Gavage) Two-generation Reproduction Toxicity Study in Sprague-Dawley Rats with Nickel Sulfate Hexahydrate. Final Report. Springborn Laboratories Inc., Spencerville. SLI Study No. 3472.4

This study was conducted to evaluate the potential effects of nickel sulfate hexahydrate when administered orally to Sprague-Dawley rats over the course of two generations.

Verougstraete V, Danzeisen R, Bruzlaff A, Oller A, Heim K, Vetter D, Müller C, Battersby RV, Oorts K, Lison D. 2017. Mechanisms underlying toxicity of complex inorganic materials. Book Chapter. Risk Management of Complex Inorganic Materials. A practical guide. Edited by V. Verougstraete. Elsevier Inc.

Verougstraete V, Henderson R, Mackie C, Newson T, Oller A. 2017. Human health (toxicity) assessment of complex inorganic materials. Book Chapter. Risk Management of Complex Inorganic Materials. A practical guide. Edited by V. Verougstraete. Elsevier Inc.

Warshaw EM, Aschenbeck KA, DeKoven JG, Maibach HI, Taylor JS, Sasseville D, Belsito DV, Fowler JF Jr, Zug KA, Zirwas MJ, Fransway AF, DeLeo VA, Marks JG Jr, Pratt MD, Mathias T, 2017. Piercing and Metal Sensitivity: Extended Analysis of the North American Contact Dermatitis Group Data, 2007-2014. Dermatitis. 28(6): 333-341.

Environmental Science

A Special Section of Environmental Toxicology and Chemistry on the Metal Mixture Modeling Evaluation Project was supported by NiPERA and guest edited by E. Garman. This section is made up of twelve articles that represent a technical review of metal mixture theory and research, syntheses of methods and results from the MMME project, technical basis and applications of bioavailability-based modeling approaches, and new metal mixture data sets. The issue was published in the April 2015 issue of ET&C 34(4).

A Special Section of Environmental Toxicology and Chemistry on the Metal Mixture Modeling Evaluation Project was supported by NiPERA and guest edited by E. Garman. This section is made up of twelve articles that represent a technical review of metal mixture theory and research, syntheses of methods and results from the MMME project, technical basis and applications of bioavailability-based modeling approaches, and new metal mixture data sets. The issue is currently available online ahead of print. The print version will appear in the March 2015 issue of ET&C.

Binet M, Adams M, Gissi F, Golding L, Schlekat C, Garman E, Merrington G, Stauber J, 2017. Toxicity of nickel to tropical freshwater and sediment biota–a critical literature review and gap analysis. Environmental Toxicology and Chemistry 10.1002/etc.3988

Blewett TA, Glover CN, Fehsenfeld S, Lawrence MJ, Niyogi S, Goss GG, Wood CM, 2015. Making sense of nickel accumulation and sub-lethal toxic effects in saline waters: Fate and effects of nickel in the green crab, Carcinus maenas. Aquat Toxicol. 164:23-33.

Blewett TA, Wood CM, 2015. Low salinity enhances NI-mediated oxidative stress and sub-lethal toxicity to the green shore crab (Carcinus maenas). Ecotoxicol Environ Saf. 122:159-70.

Brix KV, Schlekat CE, Garman E, 2016. The mechanisms of nickel toxicity in aquatic environments: An Adverse Outcome Pathway (AOP) analysis. Environ Toxicol Chem. DOI: 10.1002/etc.3706.

Brix KV, Tellis MS, Crémazy A, Wood CM, 2017. Characterization of the effects of binary metal mixtures on short-term uptake of Cd, Pb, and Zn by rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 193: 217-227. doi: 10.1016/j.aquatox.2017.10.015. Epub 2017 Oct 27.

Brix KV, Tellis MT, Crémazy A, Wood CM, 2016. Characterization of the effects of binary metal mixtures on short-term uptake of Ag, Cu, and Ni by rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology. 180: 236-246.

Chandler GT, Schlekat CE, Garman E, He L, Washburn K, Stewart E, Ferry JL, 2014. Sediment Nickel Bioavailability and Toxicity to Estuarine Crustaceans of Contrasting Bioturbative Behaviors–An Evaluation of the SEM-AVS Paradigm. Environmental Science and Technology. 48(21): 12893-901.

Costello DM, Hammerschmidt CR, Burton GA, 2016. Nickel partitioning and toxicity in sediment during aging: Variation in toxicity related to stability of metal partitioning. Environmental Science & Technology. 50: 11337-11345.

Danner KM, Hammerschmidt CR, Costello DM, Burton GA, 2015. Copper and nickel partitioning with nanoscale goethite under variable aquatic conditions. Environ Toxicol Chem. 34:1705-1710.

Farley KJ, Meyer JS, 2014. Metal Mixture Modeling Evaluation: 3. Lessons learned and steps forward. Environmental Toxicology and Chemistry. DOI: 10.1002/etc.283.

Farley KJ, Meyer JS, 2015. Metal Mixture Modeling Evaluation: 3. Lessons learned and steps forward. Environmental Toxicology and Chemistry. 34(4):821-832. DOI: 10.1002/etc.2837.

Gissi F, Stauber J, Reichelt-brushett A, Harrison PL, Jolley DF. (2017). Inhibition in fertilisation of coral gametes following exposure to nickel and copper. Ecotoxicology and Environmental Safety. 145: 32-41. doi:10.1016/j.ecoenv.2017.07.009.

Gissi F, Stauber JL, Binet MT, Golding LA, Adams MS, Schlekat C, Garman E, Jolley DF. 2016. A review of nickel toxicity to marine and estuarine tropical biota with particular reference to the South East Asian and Melanesian region. Environ Pollut. 10.1016/j.envpol.2016.08.089.

Hale B, Gopalapillai Y, Pellegrino A, Jennett T, Kikkert J, Lau W, Schlekat C, McLaughlin M, 2017. Validation of Site-Specific Soil Ni Toxicity Thresholds with Independent Ecotoxicity and Biogeochemistry Data for Elevated Soil Ni. Environmental Pollution. 231: 165-172.

Hommen U, Knopf B, Rudel H, Schafers C, De Schamphelaere K, Schlekat C, Garman E, 2015. A microcosm study to support aquatic risk assessment of nickel: Community-level effects and comparison with bioavailability-normalized species sensitivity distributions. Environmental Toxicology and Chemistry. doi: 10.1002/etc.3255.

Leonard EM, Marentette JR, Balshine S, Wood CM, 2014. Critical body residues, Michaelis-Menten analysis of bioaccumulation, lethality and behaviour as endpoints of waterborne Ni toxicity in two teleosts. Ecotoxicology. 23: 147-162.

Leonard, EM, Banerjee U, D'Silva JJ, Wood CM, 2014. Chronic nickel bioaccumulation and sub-cellular fractionation in two freshwater teleosts, the round goby and the rainbow trout, exposed simultaneously to waterborne and dietborne nickel Aquat. Toxicol. 154C: 141-153.

Mendonca R, Daley J, Hudson M, Schlekat C, Burton, Jr. GA, Costello D. 2017. Metal Oxides in Surface Sediment Control Nickel Bioavailability to Benthic Macroinvertebrates Environ Sci Technol. 51 (22): 13407-13416

Merrington G, Peters A, Schlekat C, 2016. Accounting for metal bioavailability in assessing water quality: A step change? Environ Toxicol Chem. 35: 257-265.

Meyer JS, Farley KJ, Balistrieri LS, De Schamphelaere KAC, Iwasaki Y, Janssen C, Kamo M, Lofts S, Mebane C, Naito W, Ryan AC, Santore R, Tipping E. 2015. Metal Mixture Modeling Evaluation Project: 2. Comparison of Four Modeling Approaches. Environmental Toxicology and Chemistry. 34(4):741-753. DOI: 10.1002/etc.2820.

Meyer JS, Farley KJ, Balistrieri LS, De Schamphelaere KAC, Iwasaki Y, Janssen C, Kamo M, Lofts S, Mebane C, Naito W, Ryan AC, Santore R, Tipping E., 2014. Metal Mixture Modeling Evaluation Project: 2. Comparison of Four Modeling Approaches. Environmental Toxicology and Chemistry. DOI 10.1002/etc.2820.

Meyer JS, Farley KJ, Garman ER, 2014. Metal Mixtures Modeling Evaluation: 1. Background. Environmental Toxicology and Chemistry. DOI: 10.1002/etc.2792

Meyer JS, Farley KJ, Garman ER, 2015. Metal Mixtures Modeling Evaluation: 1. Background. Environmental Toxicology and Chemistry. 34(4):726-740. DOI: 10.1002/etc.2792.

Nys C, Asselman J, Hochmuth JD, Janssen CR, Blust R, Smolders E, De Schamphelaere KAC, 2015. Mixture toxicity of nickel and zinc to Daphnia magna is noninteractive at low effect sizes but becomes synergistic at high effect sizes: Interactive effects in a binary Ni-Zn mixture Environmental Toxicology and Chemistry. 34(5). DOI:10.1002/etc.2902.

Nys C, Janssen C, van Sprang P, de Schamphelaere K, 2015. The effect of pH on chronic aquatic Ni toxicity is dependent on the pH itself: extending the chronic Ni bioavailability models. Environmental Toxicology and Chemistry. doi: 10.1002/etc.3232.

Nys C, Janssen CR, Blust R, Smolders E, De Schamphelaere K AC, 2016. Reproductive toxicity of binary and ternary mixture combinations of nickel, zinc, and lead to Ceriodaphnia dubia is best predicted with the independent action model. Environ Toxicol Chem. 35: 1796-1805. doi:10.1002/etc.3332.

Nys C, Janssen CR, Blust R, Smolders E, De Schampheleare KAC, 2015. Reproductive Toxicity of Binary and Ternary Mixture Combinations of Ni, Zn, and Pb To Ceriodaphnia Dubia Is Best Predicted With The Independent Action Model. Environmental Toxicology and Chemistry. 12/2015; DOI:10.1002/etc.3332.

Nys C, Janssen CR, Van Sprang P, De Schamphelaere KAC, 2016. The effect of pH on chronic aquatic nickel toxicity is dependent on the pH itself: Extending the chronic nickel bioavailability models. Environ Toxicol Chem. 35: 1097-1106.

Nys C, Van Regenmortel T, Janssen CR, Blust R, Smolders E, De Schamphelaere K AC, 2016. Comparison of chronic mixture toxicity of nickel-zinc-copper and nickel-zinc-copper-cadmium mixtures between Ceriodaphnia dubia and Pseudokirchneriella subcapitata. Environ Toxicol Chem. doi:10.1002/etc.3628.

Peters A, Merrington G, Schlekat C, De Schamphelaere K, Stauber J, Batley G, Harford A, van Dam R, Pease C, Mooney T, Warne M, Hickey C, Glazebrook P, Chapman J, Smith R, Krassoi R, 2018. Validation of the nickel biotic ligand model for locally relevant species in Australian freshwaters. Environmental Toxicology and Chemistry. Oct 37(10): 2566-2574.

Peters A, Schlekat CE, Merrington G, 2016. Does the Scientific Underpinning of Regulatory Tools to Estimate Bioavailability of Nickel in Freshwaters Matter? The European-Wide Environmental Quality Standard for Nickel. Environ Toxicol Chem. DOI: 10.1002/etc.3510.

Peters A, Simpson P, Merrington G, Schlekat C, Rogevich Garman E, 2014. Assessment of the effects of nickel on benthic macroinvertebrates in the field. Environmental Science and Pollution Research. 21: 193-204.

Ruden C, Adams J, Agerstrand M, Brock TCM, Poulsen V, Schlekat CE, Wheeler JR, Henry TR, 2016. Assessing the relevance of ecotoxicological studies for regulatory decision-making. Integrated Environmental Assessment and Management. DOI: 10.1002/ieam.1846.

Schlekat CE, Garman ER, Vangheluwe MLU, Burton GA Jr, 2015. Development of a bioavailability-based risk assessment approach for Ni in sediments. Integrated Environmental Assessment and Management. doi: [10.1002/ieam.1720].

Schlekat CE, Garman ER, Vangheluwe MLU, Burton GA Jr, 2016. Development of a bioavailability-based risk assessment approach for Ni in sediments. Integrated Environmental Assessment and Management. DOI: 10.1002/ieam.1720.

Schlekat CE, Merrington G, Leverett D, Peters A, 2017. Chemical standard derivation for the protection of aquatic life: A guided world tour. Integrated Environmental Assessment and Management. DOI: 10.1002/ieam.1919

Skeaff JM, Beaudoin R, 2014. Transformation/dissolution characteristics of a nickel matte and nickel concentrates for acute and chronic hazard classification. Integrated Environmental Assessment and Management. DOI: 10.1002/ieam.1573.

Skeaff JM, Beaudoin R, 2015. Transformation/Dissolution Characteristics of a Nickel Matte and Nickel Concentrates for Acute and Chronic Hazard Classification. Integrated Environmental Assessment and Management. 11(1). DOI:10.1002/ieam.1573.

Tellis MS, Lauer MM, Nadella SR, Bianchini A, Wood CM, 2014. The effects of Cu and Ni on the embryonic life stages of the purple sea urchin (Strogylocentrotus purpuratus). Archiv. Environ. Contam. Toxicol. DOI: 10.1007/s00244-014-0069-8.

Traudt EM, Ranville J F, Smith SA, Meyer JS, 2016. A test of the additivity of acute toxicity of binary-metal mixtures of Ni with Cd, Cu, and Zn to Daphnia magna, using the inflection point of the concentration–response curves. Environ Toxicol Chem. 35: 1843-1851. doi:10.1002/etc.3342.

Traudt EM, Ranville JF, Meyer JS, 2017. Effect of age on acute toxicity of cadmium, copper, nickel, and zinc in individual-metal exposures to Daphnia magna neonates. Environ Toxicol Chem. 36: 113-119. doi:10.1002/etc.3507.

Van Genderen E, Adams W, Dwyer R, Garman E, Gorsuch J, 2015. Modeling and Interpreting Biological Effects of Mixtures in the Environment Introduction to the Metal Mixture Modeling Evaluation Project. Environmental Toxicology and Chemistry. Apr 34(4): 721-5.

Van Genderen E, Adams W, Dwyer R, Garman ER, Gorsuch J, 2015. Modeling and Interpreting Biological Effects of Mixtures in the Environment Introduction to the Metal Mixture Modeling Evaluation Project. Environmental Toxicology and Chemistry. 34(4):721-5. DOI: 10.1002/etc.2750.

 

 

Below are two reports on the rapid removal from the water column method development and supporting studies that illustrates how the T/DP-E may be combined with additional findings to support the weight of evidence evaluation for nickel removal from the water column.

University of Michigan Report on Nickel-Specific Research (February 2018)

Kent State University Report on Nickel-Specific Research (January 2018)