Nickel is a naturally occurring element (the 24th most abundant element in the periodic table) and as a consequence of natural and man-made processes nickel substances can be found ubiquitously in the air, soil, sediments, and water. Human exposure to nickel substances is therefore possible in the general population as well as in specific workplaces where nickel substances are produced or used. Risk to humans depends on the type of nickel substance, the level and route of exposure, and the toxicity endpoints of concern.
The Nickel and Human Health Fact Sheet series is a resource created by NiPERA, with input from other relevant groups as appropriate, to communicate the concepts and current knowledge on human health issues to industry, regulatory authorities, and the general public. Future topics include information on hazard identification, hazard assessment, dose-response evaluation, and risk characterization for different human health endpoints, routes of exposure, and populations. The purpose of the fact sheets is to assist the reader in understanding the diverse and complex issues and concepts involved in assessing human health risk by summarizing key technical information. Currently, one fact sheet is available:
Fact Sheet 1: Nickel Allergic Contact Dermatitis
Additional Nickel and Human Health Fact Sheets are under development and will be made available as soon as they are completed.
Additional resources corresponding to the final reports for reproductive developmental toxicity study in rats are available by clicking here.