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Skin sensitisers (14047)
By G.N. Flint, reprinted from Contact Dermatitis, November, 1998. It is well known that some metals/alloys are sensitising by skin contact but it is not so well appreciated that sensitisation is dependent on reaction of the metal/alloy with sweat. The first step in skin sensitisation by metals/alloys is a corrosion process and formation of soluble metal ions. The nature of this process has implications with respect to occurrence of metal contact dermatitis; to testing techniques and to classification of metals/alloys as skin sensitisers.

